主讲人：Dr. Limsoon Wong
讲座地点：Room 610, Life Science Building, Peking University
讲座日期：2009-07-22
Abstract:
Human genome harbors millions of common single nucleotide polymorphisms (SNPs). These SNPs play an important role in understanding the correlation between genetic variations and human diseases. Genotyping all SNPs are very expensive. Fortunately, adjacent SNPs are often not independent. It is thus desirable to select a subset of SNPs that are sufficient to infer all the other SNPs. These selected SNPs are called tag SNPs. This talk presents the works on this problem with my colleagues (Guimei Liu, Yue Wang). We propose an algorithm called FastTagger to select tag SNPs based on multi-marker correlations. FastTagger is many times faster than existing tag SNP selection algorithms, and consumes much less memory. It can also effectively reduce the number of selected tag SNPs by about 40%.
Biography:
Limsoon Wong is a professor of computer science and a professor of pathology at the National University of Singapore. He currently works mostly on knowledge discovery technologies and their application to biomedicine. Limsoon has written about 150 research papers, some of which are among the best cited of their respective fields. He serves on the editorial boards of Information Systems (Elsevier), Journal of Bioinformatics and Computational Biology (ICP), Bioinformatics (OUP), and Drug Discovery Today (Elsevier). He is chairman of Molecular Connections.
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